- "Who wants to be a widow?"
- — Araña's last words to Wesley
Araña was first seen at the end of CLUSTERF**K when Wesley confronted her right after killing the SWAT Leader but was driven off by Pekwarsky who shot and missed her, next she was seen in RUSSIAN'S LAST DANCE talking to The Russian about Fox's corpse. Later, when Pekwarsky met his buyer, Brummel, Araña noticed Wesley just as he shot at Brummel with a Sniper Rifle.
In SPIDERS DON'T HAVE WINGS, Wesley fought through the mountain resort where Araña was hiding. Finally, he came face to face with Araña atop a control room balcony.
Araña met her death when Wesley shot the straps from which she was hanging outside the balcony. She grabbed the railing to stop herself falling, but when Wesley pulled the Kill Order she was holding from her grasp, this caused her to plummet to her death.
- It is implied from the quotes and the in-game art and wallpaper that Araña had some feelings for Wesley.
- She is voiced by Spanish actress Paz Vega.